How can you know your call to ministry is from the Lord? In the Bible, people such as Samuel (1 Sam 3:4-10) and Isaiah (Isa 6:8) experienced direct, audible calls from God. These instances left no doubt about the divine origin of call to ministry. However, these cases were unique and often accompanied significant shifts in God’s work in history. Today, God still calls people to ministry, but He does so through less overt means.